Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSQL19)

Drug Name

MAGGIEMYCIN Drug Info

Synonyms

Maggiemycin; 81341-47-1; methyl (1R,2R)-2-ethyl-2,5,7,12-tetrahydroxy-4,6,11-trioxo-1,3-dihydrotetracene-1-carboxylate; AC1Q6OOS; CTK3E8246; DTXSID70231061; AC1L3370; 1-naphthacenecarboxylic acid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7,12-tetrahydroxy-4,6,11-trioxo-, methyl ester,(1r-trans)-; 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7,12-tetrahydroxy-4,6,11-trioxo-, methyl ester, (1R-trans)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 133657
CAS Number: CAS 81341-47-1
TTD Drug ID: DMSQL19

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E7820	DMZRXTL	Colorectal cancer	2B91.Z	Phase 2	[2]
3-(3-(carbamoyl)benzamido)propanoic acid	DM31JAZ	Discovery agent	N.A.	Investigative	[3]
3-(3-(benzamido)-5-nitrobenzamido)propanoic acid	DMY4VX2	Discovery agent	N.A.	Investigative	[3]
3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid	DM2K51S	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Integrin alpha-2 (ITGA2)	TTSJ542	ITA2_HUMAN	Inhibitor	[1]

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References

1	Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function. J Med Chem. 2007 May 31;50(11):2742-6.
2	Phase I study of E7820, an oral inhibitor of integrin alpha-2 expression with antiangiogenic properties, in patients with advanced malignancies. Clin Cancer Res. 2011 Jan 1;17(1):193-200.
3	Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7.