Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSR91U)

Drug Name

AVE0118 Drug Info

Synonyms

UNII-Q1B712V03A; AVE-0118; CHEMBL1671897; Q1B712V03A; 498577-53-0; CHDSRMIDIQABTP-UHFFFAOYSA-N; SCHEMBL498292; ZINC3986746; BDBM50417943; SB17438; NCGC00386732-01; (1,1'-Biphenyl)-2-carboxamide, 2'-((((4-methoxyphenyl)acetyl)amino)methyl)-N-(2-(3-pyridinyl)ethyl)-; 2'-((2-(4-Methoxyphenyl)acetylamino)methyl)biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide; (1,1'-Biphenyl)-2-carboxamide, 2'-(((2-(4-methoxyphenyl)acetyl)amino)methyl)-N-(2-(3-pyridinyl)ethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Obstructive sleep apnea	7A41	Phase 1	[1]

Cross-matching ID

PubChem CID: 9811357
CAS Number: CAS 498577-53-0
TTD Drug ID: DMSR91U

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Potassium channel unspecific (KC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[3]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[3]
Dronedarone	DMA8FS5	Angina pectoris	BA40	Approved	[4]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[3]
Amifampridine	DMK08L3	LambertEaton myasthenic syndrome	8C62	Approved	[5]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[3]
Pinacidil	DMRADYL	High blood pressure	BA00	Approved	[3]
Dalfampridine	DMM0PDO	Multiple sclerosis	8A40	Approved	[6]
Ibutilide	DMKXY2R	Atrial fibrillation	BC81.3	Approved	[3]
Diazoxide	DML1538	Congenital hyperinsulinism	5A4Y	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Potassium channel unspecific (KC)	TT1VOHK	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019047)
2	Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries.Basic Clin Pharmacol Toxicol.2014 Oct;115(4):315-20.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.