Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMST4OR)

Drug Name

Selgantolimod Drug Info

Synonyms

2004677-13-6; 4-yl)amino]-2-methylhexan-1-ol; GS-9688; (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-; (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol; (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol; Selgantolimod (USAN/INN); CHEMBL4594258; SCHEMBL18109405; GTPL10889; EX-A4247; GS9688; HY-109137; compound (R)-7 [PMID: 32407112]; CS-0086927; D11871; U57

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B	1E51	Phase 2	[1]

Cross-matching ID

PubChem CID: 122585078
TTD Drug ID: DMST4OR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Toll-like receptor 8 (TLR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Resiquimod	DML6XSP	Actinic keratosis	EK90.0	Phase 2	[3]
Afimetoran	DM3HN3U	Systemic lupus erythematosus	4A40.0	Phase 2	[4]
NKTR-262	DMYR8LF	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
CPG 52364	DMVDYTG	Systemic lupus erythematosus	4A40.0	Phase 1	[6]
CV8102	DMYD37G	Melanoma	2C30	Phase 1	[7]
MEDI9197	DM0J7UR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
SBT6050	DMHBD3T	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
VTX-1463	DM4ZIRK	Allergic rhinitis	CA08.0	Phase 1	[10]
DN1508052	DM0JT9C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
GSK5251738	DM8Y6DR	Hepatitis B	1E51	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 8 (TLR8)	TT8CWFK	TLR8_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT03491553) Safety, Tolerability and Antiviral Activity of Selgantolimod in Virally-Suppressed Adults With Chronic Hepatitis B. U.S. National Institutes of Health.
2	Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J Med Chem. 2020 Sep 24;63(18):10188-10203.
3	TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
5	Clinical pipeline report, company report or official report of Nektar Therapeutics.
6	Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007.
7	Clinical pipeline report, company report or official report of CureVac.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Clinical pipeline report, company report or official report of Silverback Therapeutics.
10	VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs. 2011 Jul;20(7):981-6.
11	Clinical pipeline report, company report or official report of Shanghai De Novo Pharmatech.
12	Clinical pipeline report, company report or official report of GlaxoSmithKline