Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSW5XJ)

Drug Name

RV521 Drug Info

Synonyms

RV521 free base; UNII-KE63TTO7WK; KE63TTO7WK; RV-521; 1903763-82-5 (free base); 1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one; 1903763-82-5; Sisunatovir; CHEMBL4297497; SCHEMBL19470916; EX-A4653; RV 521; NCC1=CC2=C(N(C(=N2)CN2C(C3(C4=CC=C(C=C24)F)CC3)=O)CCCC(F)(F)F)C=C1; 1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl}-6'-fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one; Spiro(cyclopropane-1,3'-(3H)indol)-2'(1'H)-one, 1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl)methyl)-6'-fluoro-; WVA

Indication

Disease Entry	ICD 11	Status	REF
Respiratory syncytial virus infection	1C80	Phase 2	[1]

Cross-matching ID

PubChem CID: 132016492
CAS Number: CAS 1903763-82-5
TTD Drug ID: DMSW5XJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Respiratory syncytial virus protein F (RSV F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lasofoxifene	DMHA18P	Osteoporosis	FB83.0	Approved	[3]
Palivizumab	DMQM9S0	Respiratory syncytial virus infection	1C80	Approved	[4]
SAR438584	DMDMAE4	Respiratory syncytial virus infection	1C80	Phase 3	[5]
Motavizumab	DMB24H7	Respiratory syncytial virus infection	1C80	Phase 3	[6]
MK-1654	DM2YNMI	Respiratory syncytial virus infection	1C80	Phase 2/3	[7]
GS-5806	DMDAHL6	Respiratory syncytial virus infection	1C80	Phase 2	[8]
JNJ-53718678	DMJ1FXL	Respiratory syncytial virus infection	1C80	Phase 2	[9]
MEDI-557	DM6ADMG	Respiratory syncytial virus infection	1C80	Phase 1	[6]
TMC-353121	DMDSJO8	Respiratory syncytial virus infection	1C80	Preclinical	[3]
CL-387626	DMA4DNX	Virus infection	1A24-1D9Z	Terminated	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Respiratory syncytial virus protein F (RSV F)	TT57ID8	FUS_HRSVA	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03258502) Safety, Pharmacokinetics and Antiviral Activity of RV521 Against RSV. U.S. National Institutes of Health.
2	Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Apr 8;64(7):3658-3676.
3	Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection. Curr Opin Drug Discov Devel. 2009 Jul;12(4):479-87.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040470)
6	Motavizumab. Correction in: MAbs. 2010 Sep-Oct; 2(5): 591.
7	A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nat Commun. 2019 Sep 12;10(1):4153.
8	Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-43.
9	Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study. J Infect Dis. 2018 Jul 24;218(5):748-756.
10	Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein. Viruses. 2013 January; 5(1): 211-225.