Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSWUNX)

Drug Name

Naratuximab emtansine Drug Info

Synonyms

DEBIO 1562

Indication

Disease Entry	ICD 11	Status	REF
Diffuse large B-cell lymphoma	2A81	Phase 2	[1]
Non-hodgkin lymphoma	2B33.5	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Leukocyte antigen CD37 (CD37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Otlertuzumab	DMAZIND	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[3]
BI-836826	DMWH7Z5	Diffuse large B-cell lymphoma	2A81	Phase 2	[4]
IMGN529	DMNJ491	Non-hodgkin lymphoma	2B33.5	Phase 2	[5]
TRU-016	DM9IQ4A	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[6]
GEN3009	DMD8RLY	B-cell non-hodgkin lymphoma	2B33.5	Phase 1/2	[7]
212Pb-labelled aCD37	DMLVADH	leukaemia	2A60-2B33	Preclinical	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT02564744) Study to Evaluate the Efficacy and Tolerability Debio 1562 in Combination With Rituximab in Patients With Relapsed and/or Refractory DLBCL and Other Forms of NHL. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Debiopharm.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Anti-CD37 antibodies for chronic lymphocytic leukemia. Expert Opin Biol Ther. 2014 May;14(5):651-61.
5	The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. Leukemia. 2014 Jul;28(7):1501-10.
6	TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Curr Opin Investig Drugs. 2009 Dec;10(12):1383-90.
7	Clinical pipeline report, company report or official report of AbbVie.
8	Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608.