Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTAEMB)

Drug Name

AX-200 Drug Info

Synonyms

Filgrastim (stroke, ALS), Sygnis; Granulocyte colony stimulating factor (stroke, ALS), Sygnis; Granulocyte colony stimulating factor (intravenous, peripheral arterial occlusive disease/spinal cord injury/stroke/Parkinsons disease), Axaron; G-CSF (protein recombinant/iv, stroke/ALS/PAO/PD/SCI), Sygnis

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMTAEMB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Granulocyte colony-stimulating factor receptor (G-CSF-R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tbo-Filgrastim	DML6OE7	Neutropenia	4B00.0	Approved	[3]
Pegfilgrastim	DM7UP8X	Central nervous system neoplasm		Approved	[4]
Peg-G-CSF	DMBKWAF	Solid tumour/cancer	2A00-2F9Z	Phase 3	[5]
BLZ-945	DMG1LVA	Amyotrophic lateral sclerosis	8B60.0	Phase 2	[5]
SBC-014	DMG1VXR	Neutropenia	4B00.0	Phase 2	[6]
MAXY-G34	DMWLIPJ	Neutropenia	4B00.0	Phase 2	[7]
PLX7486	DM0IVGU	Pancreatic cancer	2C10	Phase 1	[8]
AMG 820	DMB6Q19	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
MK-6302	DMZUA5C	Neutropenia	4B00.0	Phase 1	[10]
PLX-5622	DMK4PWM	Autoimmune diabetes	5A10	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte colony-stimulating factor receptor (G-CSF-R)	TTC70AJ	CSF3R_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00132470) Treatment With AX200 for Acute Ischemic Stroke. U.S. National Institutes of Health.
2	Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct;44(10):2681-7.
3	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4	Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
6	A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.
7	Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38.
8	National Cancer Institute Drug Dictionary (drug id 747694).
9	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10	Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
11	Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527.