General Information of Drug (ID: DMTAI2F)

Drug Name
Acapatamab Drug Info
Synonyms AMG160
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMTAI2F

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Blinatumomab DMGECIJ Acute lymphoblastic leukaemia 2A85 Approved [3]
Mosunetuzumab DM15ZIB Follicular lymphoma 2A80 Approved [4]
Epcoritamab DMEX86V Diffuse large B-cell lymphoma 2A81 Approved [5]
Talquetamab DMXRENI Multiple myeloma 2A83 Approved [6]
Elranatamab DMG1MW2 Multiple myeloma 2A83 Approved [7]
Nivatrotamab DMAOUZV Small-cell lung cancer 2C25.Y Phase 2 [8]
Otelixizumab DMFNDBC Type-1 diabetes 5A10 Phase 2 [9]
Plamotamab DMOV28A Diffuse large B-cell lymphoma 2A81 Phase 2 [10]
Odronextamab DMP6NVV B-cell non-hodgkin lymphoma 2B33.5 Phase 2 [11]
Tarlatamab DME33OU Small-cell lung cancer 2C25.Y Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capromab DMHERIJ Prostate cancer 2C82.0 Approved [13]
PSMA-11 Ga-68 DMWLTU2 Diagnostic imaging N.A. Approved [14]
Lutetium Lu-177 vipivotide tetraxetan DMQ0IZ6 Prostate cancer 2C82.0 Approved [15]
177-Lu-PSMA-617 DMX178V Prostate cancer 2C82.0 Phase 3 [16]
BAY 2315497 DMUHH2G Prostate cancer 2C82.0 Phase 3 [17]
J 591 Lu-177 DM9XKJU Prostate cancer 2C82.0 Phase 2 [18]
G-202 DMQR9I8 Adenocarcinoma 2D40 Phase 2 [19]
ATL101 DMYAQV2 Influenza virus infection 1E30-1E32 Phase 2 [20]
99mTc-MIP-1404 DML4GU1 Prostate cancer 2C82.0 Phase 2 [21]
MLN-591RL DMJHVZC Prostate cancer 2C82.0 Phase 2 [22]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate carboxypeptidase II (GCPII) TT9G4N0 FOLH1_HUMAN Not Available [2]
T-cell surface glycoprotein CD3 (CD3) TTUN7MC NOUNIPROTAC Not Available [2]

References

1 ClinicalTrials.gov (NCT04631601) A Master Protocol Evaluating the Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (mCRPC). U.S.National Institutes of Health.
2 The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer. Clin Cancer Res. 2021 May 15;27(10):2928-2937.
3 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4 Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling. NPJ Syst Biol Appl. 2020 Aug 28;6(1):28.
5 Clinical pipeline report, company report or official report of Genmab.
6 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761342
7 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761345
8 Clinical pipeline report, company report or official report of Y-mAbs Therapeutics.
9 Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes.Diabetes Care.2014 Oct;37(10):2746-54.
10 Plamotamab (XmAb(?)13676) for Ibrutinib- refractory CXCR4-mutated extramedullary Waldenstr?m macroglobulinemia. Leuk Lymphoma. 2022 Mar;63(3):738-742.
11 Odronextamab, a human CD20*CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial. Lancet Haematol. 2022 May;9(5):e327-e339.
12 Tarlatamab, a First-in-Class DLL3-Targeted Bispecific T-Cell Engager, in Recurrent Small-Cell Lung Cancer: An Open-Label, Phase I Study. J Clin Oncol. 2023 Jun 1;41(16):2893-2903.
13 Synergistic value of single-photon emission computed tomography/computed tomography fusion to radioimmunoscintigraphic imaging of prostate cancer. Semin Nucl Med. 2007 Jan;37(1):17-28.
14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
15 [177Lu-PSMA-617 therapy, dosimetry and follow-up in patients with metastatic castration-resistant prostate cancer]. Nuklearmedizin. 2016 Jun 28;55(3):123-8.
16 Review of 177Lu-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer. Cureus. 2020 Jun 30;12(6):e8921.
17 ClinicalTrials.gov (NCT03724747) Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Antitumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate Alone and in Combination With Darolutamide, in Patients With Metastatic Castration Resistant Prostate Cancer. U.S. National Institutes of Health.
18 Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Clin Cancer Res. 2013 Sep 15;19(18):5182-91.
19 National Cancer Institute Drug Dictionary (drug id 666090).
20 Clinical pipeline report, company report or official report of Atlab pharma.
21 99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer. J Nucl Med. 2013 Aug;54(8):1369-76.
22 Indium 111-labeled J591 anti-PSMA antibody for vascular targeted imaging in progressive solid tumors. EJNMMI Res. 2015 Apr 29;5:28.