General Information of Drug (ID: DMTB4R8)

Drug Name
BAY1125976 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
PubChem CID
70817911
CAS Number
CAS 1402608-02-9
TTD Drug ID
DMTB4R8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [3]
ARQ 092 DM5WK0J Proteus syndrome LD2C Phase 2 [2]
MK-2206 DMT1OZ6 Rectal adenocarcinoma 2B92 Phase 2 [4]
GSK2141795 DMSHE70 Colorectal cancer 2B91.Z Phase 2 [5]
M2698 DM3PVBJ Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
LYS-6KAKT1 DMLXGAI Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
LY2780301 DM93AJW Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
XL418 DME0F5W Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
SR13668 DMO5760 Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
TCN-P DMV0AH8 Acute myeloid leukaemia 2A60 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RAC-gamma serine/threonine-protein kinase (AKT3) TTAZ05C AKT3_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01915576) Phase I Dose Escalation Study With an Allosteric AKT 1/2 Inhibitor in Patients. U.S. National Institutes of Health.
2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3 The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood. 2014 Oct 2;124(14):2190-5.
4 First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors.J Clin Oncol.2011 Dec 10;29(35):4688-95.
5 Inhibiting the akt pathway in cancer treatment: three leading candidates. P T. 2011 Apr;36(4):225-7.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 DOI: 10.1016/S1359-6349(10)71767-5
8 A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9.
9 Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer
10 Phase 0 clinical chemoprevention trial of the Akt inhibitor SR13668. Cancer Prev Res (Phila). 2011 Mar;4(3):347-53.
11 Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT.Invest New Drugs.2011 Dec;29(6):1381-9.