Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTKU46)

Drug Name

Bismuth Drug Info

Synonyms

Bismut; Bismuto; Wismut; Bismuth standard for AAS; Bismuth standard for ICP; LTBB002773; Bismuth(III) nitrate solution; Bismuth, elemental; Bismuth-209; BISMUTH, 99.95%; BISMUTH, 99.999%; 83Bi

Indication

Disease Entry	ICD 11	Status	REF
Diarrhea	ME05.1	Approved	[1]

Therapeutic Class

Antidiarrheals

Cross-matching ID

PubChem CID: 5359367
ChEBI ID: CHEBI:33301
CAS Number: CAS 7440-69-9
TTD Drug ID: DMTKU46

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Serum albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gadobenate Dimeglumine	DM4VAOG	Schizophrenia	6A20	Approved	[3]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[4]
Oxyphenbutazone	DMPZS7U	Arthritis	FA20	Approved	[5]
Iodipamide	DMXIQYS	Gallbladder disease	DC11.3	Approved	[6]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[7]
Gadofosveset	DM5V9U1	Imaging	QA0B	Approved	[8]
Albumin Human	DM5JTPU	Hypoalbuminemia	5C53.2	Approved	[9]
EVANS BLUE	DM5GT1M	Abdominal aortic aneurysm	BD50.4	Approved	[10]
Activated recombinant FVII-albumin fusion protein	DMKY9GI	Hemophilia	3B10.0	Phase 2/3	[11]
Vobarilizumab	DM9KNJT	Rheumatoid arthritis	FA20	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serum albumin (ALB)	TTFNGC9	ALBU_HUMAN	Binder	[2]

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References

1	The effect of histamine H2-receptor blockade on bismuth absorption from three ulcer-healing compounds. Gastroenterology. 1991 Oct;101(4):889-94.
2	Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35.
3	Protocol design for high relaxivity contrast agents in MR imaging of the CNS. Eur Radiol. 2006 Nov;16 Suppl 7:M3-7.
4	Some properties of the interaction between 2,2'-diselenadibenzoic acid and serum albumins. J Pharm Biomed Anal. 2005 Sep 1;39(1-2):263-7.
5	Effect of albumin conformation on binding of phenylbutazone and oxyphenbutazone to human serum albumin. J Pharm Sci. 1982 Feb;71(2):241-4.
6	Determining binding sites of drugs on human serum albumin using FIA-QCM. Biosens Bioelectron. 2008 Sep 15;24(1):48-54.
7	Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte. Biochem Pharmacol. 1994 Sep 15;48(6):1137-44.
8	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
11	ClinicalTrials.gov (NCT01542619) A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers. U.S. National Institutes of Health.
12	Clinical pipeline report, company report or official report of Ablynx.