General Information of Drug (ID: DMTM1LK)

Drug Name
YM-355179 Drug Info
Synonyms YM-355179; GTPL793; SCHEMBL3808393
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Preclinical [1]
Cross-matching ID
PubChem CID
11556309
TTD Drug ID
DMTM1LK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AKST4290 DM27ZJG Parkinson disease 8A00.0 Phase 2 [3]
AZD-1744 DMCOMG5 Asthma CA23 Discontinued in Phase 1 [4]
DPC-168 DMA7DH0 Allergic rhinitis CA08.0 Discontinued in Phase 1 [5]
YM-344031 DMMUYC2 Asthma CA23 Preclinical [2]
QAP-642 DM8RHST Allergic rhinitis CA08.0 Terminated [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-C chemokine receptor type 3 (CCR3) TTD3XFU CCR3_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 793).
2 Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
3 SAFETY AND THERAPEUTIC EFFECTS OF ORALLY ADMINISTERED AKST4290 IN NEWLY DIAGNOSED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina. 2022 Jun 1;42(6):1038-1046.
4 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5 CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7.
6 New Drugs and Targets for Asthma and COPD. T.T. Hansel, P.J. Barnes. 2010. Page 158.