Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTP9ER)

Drug Name

D-20133 Drug Info

Synonyms

OMPEP; octadecyl-(2-(N-methylpiperidino)ethyl)phosphate; 146764-26-3; D 20133; 1-(2-((Hydroxy(octadecyloxy)phosphinyl)oxy)ethyl)-1-methylpiperidinium inner salt; Piperidinium, 1-(2-((hydroxy(octadecyloxy)phosphinyl)oxy)ethyl)-1-methyl-, inner salt; SCHEMBL2293548; AC1L31K0; DTXSID90163471; LS-116681; 2-(1-methylpiperidin-1-ium-1-yl)ethyl octadecyl phosphate

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 132778
TTD Drug ID: DMTP9ER

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Phospholipase C (PLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphonate	DMAJ9ZD	leukaemia	2A60-2B33	Terminated	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phospholipase C (PLC)	TT1UZQH	NOUNIPROTAC	Inhibitor	[2]

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References

1	Antineoplastic activity and tolerability of a novel heterocyclic alkylphospholipid, D-20133. Cancer Chemother Pharmacol. 1993;32(6):437-44.
2	Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain. Curr Med Chem. 2011; 18(18): 2727-2742.
3	Inhibition of phosphatidylinositol-specific phospholipase C by phosphonate substrate analogues. Biochim Biophys Acta. 1990 Feb 23;1042(3):410-2.