Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTUKW9)

Drug Name
MORAb-066 Drug Info
Synonyms Anti-tissue factor monoclonal antibody (pancreatic tumor), Morphotek
Indication
Disease Entry ICD 11 Status REF
Pancreatic cancer 2C10 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMTUKW9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tisotumab vedotin DMF8FK3 Cervical cancer 2C77.0 Approved [4]
ALT-836 DMGJ71F Adult respiratory distress syndrome CB00 Phase 2 [5]
TT-173 DMSIXG4 Bleeding disorder GA20-GA21 Phase 2 [6]
D-Pro-Phe-Arg chloromethyl ketone DMRJQ8X Discovery agent N.A. Investigative [7]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tissue factor (F3) TT38MDJ TF_HUMAN Not Available [3]

References

1 ClinicalTrials.gov (NCT01761240) Dose Escalation Study MORAb-066 Targeting TF-expressing Malignancies Including Breast, Pancreatic, Colorectal, NSCLC. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Morphotek.
4 FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 761208.
5 ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment. Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1295-303.
6 TETIS study: evaluation of new topical hemostatic agent TT-173 in tooth extraction. Clin Oral Investig. 2016 Jun;20(5):1055-63.
7 Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80.