Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU4G9J)

Drug Name
CAR-T cells targeting PSCA Drug Info
Indication
Disease Entry ICD 11 Status REF
Pancreatic cancer 2C10 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMU4G9J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostate stem cell antigen (PSCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anti-PSCA mab DMJPZDC Pancreatic cancer 2C10 Phase 2 [3]
BPX-601 DMV9QGW Gastric adenocarcinoma 2B72 Phase 1/2 [4]
GEM3PSCA DM3GSPR Non-small-cell lung cancer 2C25 Phase 1 [5]
MB-105 DMVGTP6 Prostate cancer 2C82.0 Phase 1 [6]
Anti-PSCA mab DMJPZDC Pancreatic cancer 2C10 Phase 2 [3]
BPX-601 DMV9QGW Gastric adenocarcinoma 2B72 Phase 1/2 [4]
GEM3PSCA DM3GSPR Non-small-cell lung cancer 2C25 Phase 1 [5]
MB-105 DMVGTP6 Prostate cancer 2C82.0 Phase 1 [6]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostate stem cell antigen (PSCA) TT9T4AV PSCA_HUMAN CAR-T-Cell-Therapy [1]

References

1 ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer.
2 ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers
3 Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial. Cancer Chemother Pharmacol. 2012 Mar;69(3):763-71.
4 ClinicalTrials.gov (NCT02744287) Use of Ligand-Inducible Autologous T Cells Engineered to Target PSCA on Tumor Cells in Selected Advanced Solid Tumors
5 Clinical pipeline report, company report or official report of Gemoab.
6 Clinical pipeline report, company report or official report of Mustang Bio.