General Information of Drug (ID: DMU6AMP)

Drug Name
IL-2 antibody (anti-tumor) Drug Info
Synonyms DMS-1.10; anti-human rIL-2 antibody, Hybritech
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMU6AMP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldesleukin DM4YMIS Acute myelogenous leukaemia 2A41 Approved [2]
Daclizumab DM6OZQV Aplastic anemia 3A70 Approved [3]
AIR-insulin DM8SYTE Diabetic complication 5A2Y Phase 3 [4]
TG-4010 DMWE3GB Bipolar disorder 6A60 Phase 2/3 [5]
BNZ-1 DM8JQZC Cutaneous T-cell lymphoma 2B01 Phase 2 [6]
IL-2/CD40L-expressing leukemia vaccine DMIHQ5G Chronic lymphocytic leukaemia 2A82.0 Phase 2 [7]
Carboxyamidotriazole orotate DMN5JCX Glioblastoma multiforme 2A00.0 Phase 2 [8]
Leuvectin DM5LQEI Melanoma 2C30 Phase 2 [9]
Human interleukin-2 DM0NJWG Renal cell carcinoma 2C90 Phase 2 [10]
L19-IL-2 fusion protein DMI2XP1 Lymphoma 2A80-2A86 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-2 (IL2) TTF89GD IL2_HUMAN Modulator [1]

References

1 An anti-IL-2 antibody increases serum half-life and improves anti-tumor efficacy of human recombinant interleukin-2. Immunopharmacology. 1994 Nov-Dec;28(3):223-32.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
4 The AIR inhaled insulin system: system components and pharmacokinetic/glucodynamic data. Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S41-7.
5 A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol. 2008 Jul;3(7):735-44.
6 Clinical pipeline report, company report or official report of Bioniz Therapeutics.
7 Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and a... Blood. 2006 Feb 15;107(4):1332-41.
8 J Clin Oncol 32:5s, 2014 (suppl; abstr 2071).
9 Intratumoral interleukin 2 for renal-cell carcinoma by direct gene transfer of a plasmid DNA/DMRIE/DOPE lipid complex. World J Urol. 2000 Apr;18(2):152-6.
10 Clinical pipeline report, company report or official report of Immunservice.
11 National Cancer Institute Drug Dictionary (drug id 665656).