Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU8KOD)

Drug Name

Anakinra Drug Info

Synonyms

Kineret; Kineret (TN); Anakinra (USAN/INN)

Indication

Therapeutic Class

Antiinflammatory Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Interleukin 1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SB 203580	DMAET6F	N. A.	N. A.	Terminated	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 1 receptor type 1 (IL1R1)	TTWOTEA	IL1R1_HUMAN	Antagonist	[4]
HUMAN interleukin-1 receptor 1 (IL1R1)	TTT7FOP	IL1R1_HUMAN	Antagonist	[5]

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References

1	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (BLA) 103950.
2	ClinicalTrials.gov (NCT04364009) Anakinra for COVID-19 Respiratory Symptoms. U.S. National Institutes of Health.
3	Clinical and genetic characterization of Italian patients affected by CINCA syndrome. Rheumatology (Oxford). 2007 Mar;46(3):473-8.
4	IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes. Eur Cytokine Netw. 2009 Jun 1;20(2):81-87.
5	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (BLA) 125166.
6	IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J Cell Physiol. 2001 Jun;187(3):294-303.