Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU9K8N)

• Drug Name: AMG 193 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Aggressive cancer	2A00-2F9Z	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMU9K8N

Molecule-Related Drug Atlas

Drug(s) Targeting Protein arginine methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK3326595	DMJRD7A	Breast cancer	2C60-2C65	Phase 2	[3]
PRT811	DMW3MCX	Glioma	2A00.0	Phase 1	[4]
PRT543	DMHNZ3U	Hematologic tumour	2B33.Y	Phase 1	[5]
JNJ-64619178	DMDBW2N	Myelodysplastic syndrome	2A37	Phase 1	[6]
PF-06939999	DM7BOFR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
DS-437	DME3WBQ	Discovery agent	N.A.	Investigative	[8]
cmp5	DMBT2ZW	Discovery agent	N.A.	Investigative	[9]
EPZ015666	DM3INX7	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein arginine methyltransferase 5 (PRMT5)	TTR1D7X	ANM5_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT05094336) A Phase 1/1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 193 Alone and in Combination With Docetaxel in Subjects With Advanced MTAP-null Solid Tumors. U.S.National Institutes of Health.
• [2] AMG 193 Effective in Multiple Tumor Types. Cancer Discov. 2023 Dec 12;13(12):2492.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Clinical pipeline report, company report or official report of Prelude Therapeutics.
• [5] Clinical pipeline report, company report or official report of Prelude Therapeutics.
• [6] A patent review of arginine methyltransferase inhibitors (2010-2018). Expert Opin Ther Pat. 2019 Feb;29(2):97-114.
• [7] National Cancer Institute Drug Dictionary (drug name PF-06939999).
• [8] Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.
• [9] Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015 Apr 16;125(16):2530-43.
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1256).