Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUA0XC)

Drug Name

ALF-5755 Drug Info

Synonyms

HIP/PAP; Hepatocarcinoma-intestine-pancreas/pancreatic-associated protein

Indication

Disease Entry	ICD 11	Status	REF
Liver failure	DB99.7	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Regenerating human pro-islet peptide (REG3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HIP-2B	DM45MR0	Type-1/2 diabetes	5A10-5A11	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Regenerating human pro-islet peptide (REG3A)	TTL4H8N	REG3A_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01318525) Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure. U.S. National Institutes of Health.
2	HIP/PAP prevents excitotoxic neuronal death and promotes plasticity. Ann Clin Transl Neurol. 2014 October; 1(10): 739-754.
3	Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Am J Pathol.1999 Nov;155(5):1525-33.