Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUC6EP)

Drug Name

BIIB095 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.7 (SCN9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
XEN-402	DMR69CG	Osteoarthritis	FA00-FA05	Phase 2	[2]
PF-05089771	DMD74BJ	Chronic pain	MG30	Phase 2	[3]
BIIB074	DMLV1ET	Bipolar disorder	6A60	Phase 2	[1]
DSP-2230	DM0WTMD	Neuropathic pain	8E43.0	Phase 1	[1]
GDC0310	DMUNFEP	Chronic pain	MG30	Phase 1	[4]
DSP-3905	DMYHU24	Neuropathic pain	8E43.0	Phase 1	[1]
PF-05241328	DM2NTBL	Pain	MG30-MG3Z	Phase 1	[5]
DWJ-208	DMQKDJZ	Cancer related pain	MG30	Phase 1	[1]
RG7893	DM1R4MQ	Pain	MG30-MG3Z	Phase 1	[6]
PF-05186462	DMUF6W9	Pain	MG30-MG3Z	Phase 1	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	TT4G2JS	SCN9A_HUMAN	Inhibitor	[1]

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References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker. Pain. 2012 Jan;153(1):80-5.
3	Primary erythromelalgia: a review. Orphanet J Rare Dis. 2015 Sep 30;10:127.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041740)
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026875)