Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUFDR6)

Drug Name

Octahydrocurcumin Drug Info

Synonyms

36062-07-4; 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol; SCHEMBL645293; MEGxp0_001209; MEGxp0_001210; (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL; CHEMBL1087517; ACon1_001058; ACon1_001138; DTXSID40873750; HY-N0894; MFCD25371921; AKOS030526791; CS-3740; NCGC00169640-01; NCGC00169640-02; 1,7-Bis(3-methoxy-4-hydroxyphenyl)heptane-3,5-diol; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol; BRD-A35096796-001-01-0; BRD-A35096796-001-02-8; 3,5-dihydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

PubChem CID: 11068834
CAS Number: CAS 36062-07-4
TTD Drug ID: DMUFDR6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Exportin-1 (XPO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selinexor	DMBD4K3	Multiple myeloma	2A83	Phase 3	[3]
Selinexor oral	DMDLOBZ	Recurrent glioblastoma	2A00.00	Phase 2	[4]
Eltanexor oral	DM7CLEZ	Colorectal cancer	2B91.Z	Phase 1/2	[5]
SL-801	DMIVGYK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
KOS-1815	DMCGFY6	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
S109	DM2JYQA	Solid tumour/cancer	2A00-2F9Z	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Exportin-1 (XPO1)	TTCJUR4	XPO1_HUMAN	Inhibitor	[2]

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References

1	Octahydrocurcumin, a final hydrogenated metabolite of curcumin, possesses superior anti-tumor activity through induction of cellular apoptosis. Food Funct. 2018 Apr 25;9(4):2005-2014.
2	Therapeutic strategies targeting FOXO transcription factors. Nat Rev Drug Discov. 2021 Jan;20(1):21-38.
3	Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol. 2014 August; 0: 62-73.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-B signaling pathway. Cancer Cell Int. 2020 Mar 30;20:97.