Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUR6OV)

Drug Name

RG-7356 Drug Info

Synonyms

RO-5429083; AR-001 series, ARIUS; ARH460-16-2; ChARH460-16-2; H460-16-2; MuARH460-16-2; Anti-CD44 antibody (cancer), ARIUS; Anti-CD44 mAb (cancer), Roche; Chimeric ARH460-16-2-IgG1; Chimeric ARH460-16-2-IgG2; (ch)ARH460-16-2-IgG1; (ch)ARH460-16-2-IgG2

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Discontinued in Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMUR6OV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Hyaluronic acid receptor (LYVE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hyaluronate sodium	DMX8M26	Joint lubricant	FA30-FA38	Approved	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hyaluronic acid receptor (LYVE1)	TTG8DNU	LYVE1_HUMAN	Not Available	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034685)
2	Preclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys: Prelude to Phase 1 clinical studies. MAbs. 2014 Mar-Apr;6(2):567-75.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4954).