General Information of Drug (ID: DMURX4B)

Drug Name
Recombinant batroxobin Drug Info
Indication
Disease Entry ICD 11 Status REF
Blood forming organ disorder JB64.1 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMURX4B

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Fibrin (FG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beriplast-P DMEBY2D Wound healing EL8Y Approved [3]
Baquting DME1DJX Bleeding disorder GA20-GA21 Approved [4]
Fibrinolysin DM9Q8SO Wound healing EL8Y Approved [5]
TachoComb DM6S0HB Wound healing EL8Y Approved [6]
Adhexil DMFIP35 Injury NA00-ND5Z Phase 3 [7]
Alfimeprase DMVHRL8 Peripheral vascular disease BD4Z Phase 3 [8]
KUR-212 DMB4HCY Wound healing EL8Y Phase 2 [9]
Plasmin DMOB1EM Occlusive disease BD4Z Phase 2 [10]
KUR-211 DM2N0Z3 Ulcer CA02-CB40 Phase 2 [11]
EP-2104R DMG3R14 Cardiovascular disease BA00-BE2Z Discontinued in Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fibrin (FG) TTWODQF FIBA_HUMAN; FIBB_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028815)
2 Functional characterization of recombinant batroxobin, a snake venom thrombin-like enzyme, expressed from Pichia pastoris. FEBS Lett. 2004 Jul 30;571(1-3):67-73.
3 Wound healing and degradation of the fibrin sealant Beriplast P following partial liver resection in rabbits. Wound Repair Regen. 2005 May-Jun;13(3):318-23.
4 Baquting, enable our sales and marketing team to effectively promote our principal products and help to stimulate the sales of our other pharmaceuticals.
5 FIBRINOLYSIN, FIBRIN AND HYALINE MEMBRANES. Pediatrics. 1963 Nov;32:940-2.
6 Pancreaticojejunostomy using a fibrin adhesive sealant (TachoComb) for the prevention of pancreatic fistula after pancreaticoduodenectomy. Hepatogastroenterology. 2011 Jan-Feb;58(105):187-91.
7 Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci. Fertil Steril. 2010 Mar 1;93(4):1045-51.
8 Disulfide structure of alfimeprase: A recombinant analog of fibrolase. Protein Sci. 2001 June; 10(6): 1264-1267.
9 Clinical pipeline report, company report or official report of Kuros.
10 ClinicalTrials.gov (NCT01014975) A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients. U.S. National Institutes of Health.
11 Clinical pipeline report, company report or official report of Kuros.
12 EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus. J Am Chem Soc. 2008 May 7;130(18):6025-39.