Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUSPW5)

Drug Name

NCO-48 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B virus infection	1E51.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Hepatitis B virus Polymerase (HBV P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Telbivudine	DMSWUGE	Hepatitis B virus infection	1E51.0	Approved	[3]
ATI-2173	DMT5QYJ	Hepatitis B	1E51	Phase 2	[4]
Valtorcitabine	DMXQCBU	Hepatitis virus infection	1E50-1E51	Discontinued in Phase 2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Polymerase (HBV P)	TTT4SY6	Q67889_HBV	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04629976) Activity of NCO-48 Fumarate in Treatment-Naive Adults With Chronic Hepatitis B. U.S. National Institutes of Health.
2	Safety, Tolerability and Pharmacokinetics of NCO-48 Fumarate in Healthy Subjects
3	Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol. 2008;22(6):1081-92.
4	ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20.
5	Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. J Pharm Sci. 2008 Mar;97(3):1109-34.