General Information of Drug (ID: DMUW3MT)

Drug Name
PMID23849879C3 Drug Info
Synonyms
SMR000144080; MLS000537840; AC1LJ8QE; GTPL8488; cid_970375; BDBM32709; MolPort-002-093-912; HMS2464J20; HMS1593B09; ZINC609776; STK138150; AKOS001696771; MCULE-4952162555; SR-01000666149; SR-01000666149-2
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
970375
TTD Drug ID
DMUW3MT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Patented Agent(s)
Drug(s) Targeting Kallikrein-5 (KLK5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25489658C4d DMWZJT0 Discovery agent N.A. Investigative [2]
Drug Name Drug ID Indication ICD 11 Highest Status REF
US8569313, Inhibitor 18 DMXTCGM N. A. N. A. Patented [3]
US8569313, Inhibitor 14 DMZV6YT N. A. N. A. Patented [3]
US8569313, Inhibitor 19 DMLXG43 N. A. N. A. Patented [3]
US8569313, Inhibitor 15 DMTMG02 N. A. N. A. Patented [3]
PMID25489658C4d DMWZJT0 Discovery agent N.A. Investigative [2]
Benzamidine DM37GWL Discovery agent N.A. Investigative [4]
2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine DMFXKN1 Discovery agent N.A. Investigative [5]
Inhibitor 1 [Colombo et al., 2012] DMUQHMP Discovery agent N.A. Investigative [6]
3-tapap DMKSUV9 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Targeting Kallikrein-14 (KLK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25489658C4d DMWZJT0 Discovery agent N.A. Investigative [2]
Drug(s) Targeting Kallikrein-7 (KLK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25489658C4d DMWZJT0 Discovery agent N.A. Investigative [2]
Antileukoprotease (ALP) DMVF2YH Discovery agent N.A. Investigative [7]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kallikrein-14 (KLK14) TTDA81R KLK14_HUMAN Inhibitor [1]
Kallikrein-5 (KLK5) TTULSEW KLK5_HUMAN Inhibitor [1]
Kallikrein-7 (KLK7) TTE6GTB KLK7_HUMAN Inhibitor [1]
Suppressor of tumorigenicity 14 protein (ST14) TTPRO7W ST14_HUMAN Inhibitor [1]

References

1 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51.
2 Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612.
3 Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2418).
7 Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors. Int J Gynecol Cancer. 2001 Nov-Dec;11(6):454-61.