General Information of Drug (ID: DMUXAM8)

Drug Name
4D-110 Drug Info
Indication
Disease Entry ICD 11 Status REF
Choroideremia 9B61 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMUXAM8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIIB111 DMQCE1T Choroideremia 9B61 Phase 3 [3]
SPK-7001 DMEVGI9 Choroidal dystrophy 9B61 Phase 1/2 [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rab proteins geranylgeranyltransferase component A 1 (CHM) TTOA18V RAE1_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT04483440) Phase 1 Open-Label, Dose-Escalation Study of the Safety, Tolerability and Preliminary Efficacy of Intravitreal 4D-110 in Patients With Choroideremia. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of 4D Molecular Therapeutics
3 ClinicalTrials.gov (NCT03496012) A Randomised, Open Label, Outcomes-Assessor Masked, Prospective, Parallel Controlled Group, Phase 3 Clinical Trial of Retinal Gene Therapy for Choroideremia Using an Adeno-Associated Viral Vector (AAV2) Encoding Rab Escort Protein 1 (REP1). U.S.National Institutes of Health.
4 Clinical pipeline report, company report or official report of Spark Therapeutics.