Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV1BTP)

Drug Name

ISIS-SOD1 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Phase 1	[1]
Motor neurone disease	8B60	Phase 1	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting SOD1 messenger RNA (SOD1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 150463	DMFUM62	Discovery agent	N.A.	Investigative	[3]
ISIS 150454	DMW0Y75	Discovery agent	N.A.	Investigative	[3]
ISIS 150450	DMMBW13	Discovery agent	N.A.	Investigative	[3]
ISIS 150451	DM1DCFP	Discovery agent	N.A.	Investigative	[3]
ISIS 150452	DMQE7BH	Discovery agent	N.A.	Investigative	[3]
ISIS 150464	DM1IC54	Discovery agent	N.A.	Investigative	[3]
ISIS 150453	DMKCG41	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
2	ClinicalTrials.gov (NCT01041222) Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations. U.S. National Institutes of Health.
3	US patent application no. 7,132,530, Antisense modulation of superoxide dismutase 1, soluble expression.