Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTP9K3Q)

DTT Name SOD1 messenger RNA (SOD1 mRNA)
Synonyms hSod1 (mRNA); Superoxide dismutase [Cu-Zn] (mRNA); Superoxide dismutase 1 (mRNA); Superoxide dismutase (mRNA)
Gene Name SOD1
DTT Type
Clinical trial target
 [1]
BioChemical Class
mRNA target
UniProt ID
SODC_HUMAN
TTD ID
T29024
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.15.1.1
Sequence
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
KEGG Pathway
Peroxisome (hsa04146 )
Amyotrophic lateral sclerosis (ALS) (hsa05014 )
Huntington's disease (hsa05016 )
Prion diseases (hsa05020 )
Reactome Pathway
Detoxification of Reactive Oxygen Species (R-HSA-3299685 )
Platelet degranulation (R-HSA-114608 )
BioCyc Pathway
MetaCyc:HS06899-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tofersen DM0AEDT Amyotrophic lateral sclerosis 8B60.0 Approved [2]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS-SOD1 DMV1BTP Amyotrophic lateral sclerosis 8B60.0 Phase 1 [1]
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7 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 150450 DMMBW13 Discovery agent N.A. Investigative [3]
ISIS 150451 DM1DCFP Discovery agent N.A. Investigative [3]
ISIS 150452 DMQE7BH Discovery agent N.A. Investigative [3]
ISIS 150453 DMKCG41 Discovery agent N.A. Investigative [3]
ISIS 150454 DMW0Y75 Discovery agent N.A. Investigative [3]
ISIS 150463 DMFUM62 Discovery agent N.A. Investigative [3]
ISIS 150464 DM1IC54 Discovery agent N.A. Investigative [3]
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⏷ Show the Full List of 7 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Lateral sclerosis 8A00.0 Cervical spinal cord 2.51E-01 -0.49 -0.43
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References

1 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 US patent application no. 7,132,530, Antisense modulation of superoxide dismutase 1, soluble expression.