Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV39AW)

Drug Name

ADENOPHOSTIN A Drug Info

Synonyms

adenophostin a; 149091-92-9; Adenophostin; CHEMBL204385; AC1L3X4M; CHEBI:34524; 2'-Adenylic acid, 3'-O-(3,4-di-O-phosphono-alpha-D-glucopyranosyl)-; C16H26N5O18P3; GTPL4124; DTXSID10164167; BDBM50184325; LS-173343; C13727; 2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyphosphate-(2R,3R,4R,5R)-tetrahydro-3-furanyloxy]-6-hydroxymethyl-4,5-dioxyphosphate-(2R,3R,4S,5R,6R)-tetrahydro-2H-3-pyranol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 123695
ChEBI ID: CHEBI:34524
CAS Number: CAS 149091-92-9
TTD Drug ID: DMV39AW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Inositol 1,4,5-trisphosphate receptor (ITPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitroprusside	DMLUA2J	Hypertension	BA00-BA04	Approved	[3]
D-myo-inositol 1,4,5-trisphosphate	DMNUKIX	Discovery agent	N.A.	Investigative	[4]
5'-Deoxy-5'-phenyladenophostin A	DMU4MCK	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inositol 1,4,5-trisphosphate receptor (ITPR)	TTC9IZL	ITPR1_HUMAN; ITPR2_HUMAN; ITPR3_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4124).
2	Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. J Med Chem. 2006 Sep 21;49(19):5750-8.
3	Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem. 1996 Mar 8;271(10):5545-51.
4	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.