Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV4P7S)

Drug Name

PF-4957325-00 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Phosphodiesterase 8 (PDE8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8846654, 294	DMP3RCH	N. A.	N. A.	Patented	[2]
US8846654, 251	DMML258	N. A.	N. A.	Patented	[2]
US8846654, 11	DMRUTJZ	N. A.	N. A.	Patented	[2]
US9493447, 1001	DM4MJ3U	N. A.	N. A.	Patented	[3]
BC11-28	DMTWIE2	N. A.	N. A.	Patented	[4]
AC1M1SP5	DMEW5LD	N. A.	N. A.	Patented	[4]
PF-04957325	DMPEZKT	Inflammation	1A00-CA43.1	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One. 2010 Aug 9;5(8):e12011.
2	Therapeutic applications in the cardiovascular field of quinazolinedione derivatives. US8846654.
3	Optically active PDE10 inhibitor. US9493447.
4	Inhibitors of phosphodiesterase 11 (PDE11). US9173884.
5	Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.Front Pharmacol. 2016 Aug 23;7:259.