General Information of Drug (ID: DMV4P7S)

Drug Name
PF-4957325-00 Drug Info
Indication
Disease Entry ICD 11 Status REF
Inflammation 1A00-CA43.1 Investigative [1]
Cross-matching ID
TTD Drug ID
DMV4P7S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Drug(s) Targeting Phosphodiesterase 8 (PDE8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US8846654, 294 DMP3RCH N. A. N. A. Patented [2]
US8846654, 251 DMML258 N. A. N. A. Patented [2]
US8846654, 11 DMRUTJZ N. A. N. A. Patented [2]
US9493447, 1001 DM4MJ3U N. A. N. A. Patented [3]
BC11-28 DMTWIE2 N. A. N. A. Patented [4]
AC1M1SP5 DMEW5LD N. A. N. A. Patented [4]
PF-04957325 DMPEZKT Inflammation 1A00-CA43.1 Investigative [5]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 8 (PDE8) TTIS4OW PDE8A_HUMAN Inhibitor [1]

References

1 PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One. 2010 Aug 9;5(8):e12011.
2 Therapeutic applications in the cardiovascular field of quinazolinedione derivatives. US8846654.
3 Optically active PDE10 inhibitor. US9493447.
4 Inhibitors of phosphodiesterase 11 (PDE11). US9173884.
5 Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.Front Pharmacol. 2016 Aug 23;7:259.