Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV80DP)

Drug Name

LAS-186323 Drug Info

Synonyms

DHODH inhibitor (autoimmune disease), Alimirall; DHODH inhibitor (rheumatoid arthritis/multiple sclerosis), Almirall

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Dihydroorotate dehydrogenase (DHODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[3]
Vidofludimus	DM0POWG	Inflammatory bowel disease	DD72	Phase 2	[4]
BREQUINAR	DMKGM42	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[5]
BAY2402234	DMRL6W5	Myeloid leukaemia	2B33.1	Phase 1	[6]
HR325	DM51GZS	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[7]
FK778	DMH6QAI	Kidney/heart transplant rejection	NE84	Discontinued in Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydroorotate dehydrogenase (DHODH)	TTLVP78	PYRD_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028859)
2	Clinical pipeline report, company report or official report of Aslanpharma.
3	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4	Company report (4SC)
5	DOI: 10.1203/00006450-198807000-00137
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42.
8	Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9.