General Information of Drug (ID: DMV80DP)

Drug Name
LAS-186323 Drug Info
Synonyms DHODH inhibitor (autoimmune disease), Alimirall; DHODH inhibitor (rheumatoid arthritis/multiple sclerosis), Almirall
Indication
Disease Entry ICD 11 Status REF
Multiple sclerosis 8A40 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMV80DP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [3]
Vidofludimus DM0POWG Inflammatory bowel disease DD72 Phase 2 [4]
BREQUINAR DMKGM42 Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [5]
BAY2402234 DMRL6W5 Myeloid leukaemia 2B33.1 Phase 1 [6]
HR325 DM51GZS Rheumatoid arthritis FA20 Discontinued in Phase 2 [7]
FK778 DMH6QAI Kidney/heart transplant rejection NE84 Discontinued in Phase 2 [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dihydroorotate dehydrogenase (DHODH) TTLVP78 PYRD_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028859)
2 Clinical pipeline report, company report or official report of Aslanpharma.
3 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4 Company report (4SC)
5 DOI: 10.1203/00006450-198807000-00137
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42.
8 Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9.