General Information of Drug (ID: DMVB9XC)

Drug Name
Tanomastat Drug Info
Synonyms Tanomastat (USAN/INN); (2S)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid
Indication
Disease Entry ICD 11 Status REF
Lung cancer 2C25.0 Discontinued in Phase 3 [1]
Osteoarthritis FA00-FA05 Discontinued in Phase 3 [1]
Ovarian cancer 2C73 Discontinued in Phase 3 [1]
Pancreatic cancer 2C10 Discontinued in Phase 3 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
6918336
CAS Number
CAS 179545-77-8
TTD Drug ID
DMVB9XC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prinomastat DM9HOKG Lung cancer 2C25.0 Approved [3]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [4]
Marimastat DM6V34C Pancreatic cancer 2C10 Phase 3 [5]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [6]
Metastat DMTQ4PN Acne vulgaris ED80 Phase 1 [7]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [8]
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [8]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [8]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [8]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6468).
2 Radiation therapy and biological compounds for consolidation therapy in advanced ovarian cancer. Int J Gynecol Cancer. 2008 Mar-Apr;18 Suppl 1:44-6.
3 AG-3340 (Agouron Pharmaceuticals Inc). IDrugs. 2000 Mar;3(3):336-45.
4 Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4.
5 Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol. 2007 Mar 15;559(1):75-81.
6 Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5.
7 Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72.
8 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.