Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVIKJZ)

Drug Name

Cinryze Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hereditary angioedema	4A00.14	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting C1 esterase inhibitor (SERPING1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[3]
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Drug(s) Targeting Complement C1s component (C1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sutimlimab	DMY7WH1	Cold type autoimmune haemolytic anemia	3A20.1	Approved	[4]
SAR445088	DMQV3IM	Chronic inflammatory demyelinating polyneuropathy	8C01.3	Phase 2	[5]
TS01	DMNTVUK	Stroke	8B20	Phase 1	[6]
SHP616	DMO0CA8	Neuromyelitis optica	8A43	Phase 1	[7]
ANX005	DMAESIY	Neurodegenerative disorder	8A20-8A23	Phase 1	[8]
TNT009	DMSKF29	Bullous pemphigoid	EB41.0	Phase 1	[7]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[9]
PMID16460935C28	DM8BKI4	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C1 esterase inhibitor (SERPING1)	TTVQ6R9	IC1_HUMAN	Modulator	[2]
Complement C1s component (C1S)	TT7LRQH	C1S_HUMAN	Modulator	[2]

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References

1	Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
2	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
3	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
4	Antibodies to watch in 2020. MAbs. Jan-Dec 2020;12(1):1703531.
5	First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor. Clin Transl Sci. 2023 Apr;16(4):673-685.
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10	A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2200-4.