General Information of Drug (ID: DMVMIBY)

Drug Name
AGG-523 Drug Info
Synonyms PF-5212371, WAY-266523
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Phase 1 [1]
Cross-matching ID
PubChem CID
16048422
CAS Number
CAS 920289-29-8
TTD Drug ID
DMVMIBY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Aggrecanase (ADAMTS5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SC-44463 DMBPNKT N. A. N. A. Terminated [3]
PMID21536437C15c DM2R94W Discovery agent N.A. Investigative [4]
CR-5259 DME5IJQ Osteoarthritis FA00-FA05 Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aggrecanase (ADAMTS5) TTXSU2Y ATS5_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00454298) Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement. U.S. National Institutes of Health.
2 Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage. 2011 Mar;19(3):315-23.
3 Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50.
4 Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677).