General Information of Drug (ID: DMVRTCW)

Drug Name
HDM201 Drug Info
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Phase 1 [1]
Liposarcoma 2B59 Phase 1 [2]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
PubChem CID
71678098
CAS Number
CAS 1448867-41-1
TTD Drug ID
DMVRTCW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7388 DMF5GZI Acute myeloid leukaemia 2A60 Phase 3 [4]
APG-115 DMIFA0L Prolymphocytic leukaemia 2A82.1 Phase 2 [2]
ALRN-6924 DMLBWT1 Haematological malignancy 2B33.Y Phase 2 [2]
AMG 232 DM65PTO Merkel cell carcinoma 2C34 Phase 2 [5]
ASTX295 DM9EM5G Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
DS-3032 DMA2B5Y Haematological malignancy 2B33.Y Phase 1 [7]
RG7775 DMXBS6U Acute myeloid leukaemia 2A60 Phase 1 [8]
JNJ-26854165 DMNSJ3C Non-small-cell lung cancer 2C25.Y Phase 1 [9]
BI 907828 DM2Z4YQ Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
MI-219 DM196LK Triple negative breast cancer 2C60-2C65 Investigative [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Contusugene ladenovec DMN9ETB Oral cancer 2B6E Phase 3 [12]
QPI-1002 DMDU5Y2 Renal transplantation NE84 Phase 3 [13]
Thymoquinone DMVDTR2 Polycystic ovarian syndrome 5A80.1 Phase 2/3 [14]
APG-115 DMIFA0L Prolymphocytic leukaemia 2A82.1 Phase 2 [2]
SGT-53 DMLYIPA Pancreatic cancer 2C10 Phase 2 [15]
APR-246 DMNFADH Ovarian cancer 2C73 Phase 2 [16]
Ad-p53 DMJSWXL Solid tumour/cancer 2A00-2F9Z Phase 2 [17]
Kevetrin DMFO6MH Ovarian cancer 2C73 Phase 2 [2]
INGN-225 DMF7J6D Head and neck cancer 2D42 Phase 2 [18]
ALT-801 DM9KL7P Acute myeloid leukaemia 2A60 Phase 2 [19]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cellular tumor antigen p53 (TP53) TT7SBF5 P53_HUMAN Inhibitor [3]
Ubiquitin-protein ligase E3 Mdm2 (MDM2) TT08GJW MDM2_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT02143635) Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 National Cancer Institute Drug Dictionary (drug id 761551).
4 Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget. 2015 Apr 30;6(12):10207-21.
5 Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41.
6 Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
7 Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov. 2014 Mar;13(3):217-36.
8 Phase I clinical trail of RG7775 for treating Acute myelogenous leukemia. Roche.
9 Serdemetan antagonizes the Mdm2-HIF1alpha axis leading to decreased levels of glycolytic enzymes. PLoS One. 2013 Sep 6;8(9):e74741.
10 MDM2 inhibition: an important step forward in cancer therapy. Leukemia. 2020 Nov;34(11):2858-2874.
11 MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene. 2011 Jan 6;30(1):117-26.
12 A review of contusugene ladenovec (Advexin) p53 therapy. Curr Opin Mol Ther. 2009 Feb;11(1):54-61.
13 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
14 Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
15 Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy. Cancer Gene Ther. 2013 Apr;20(4):222-8.
16 APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013 Oct 24;4:e881.
17 Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer. Cancer Gene Ther. 2003 Mar;10(3):224-38.
18 INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert Opin Biol Ther. 2010 Jun;10(6):983-91.
19 Phase I trial of ALT-801, an interleukin-2/T-cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies. Clin Cancer Res. 2011 Dec 15;17(24):7765-75.