Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVXQ5W)

Drug Name

RO-5458640 Drug Info

Synonyms

Anti-TWEAK humanized monoclonal antibody (iv, cancer), Hoffmann-La Roche

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting TNF-related weak inducer of apoptosis (TWEAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIIB 023	DM9OXEJ	Rheumatoid arthritis	FA20	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF-related weak inducer of apoptosis (TWEAK)	TTBTDM1	TNF12_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01383733) A Study of RO5458640 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
2	A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo. MAbs. 2014 January 1; 6(1): 297-308.
3	ClinicalTrials.gov (NCT00771329) BIIB023 (Anti-TWEAK) in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.