Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW4L3K)

Drug Name
ICI-198583 Drug Info
Synonyms 112887-62-4; CB-3819
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
135400203
CAS Number
CAS 112887-62-4
TTD Drug ID
DMW4L3K

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thymidylate synthase (TYMS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Plevitrexed (R)-isomer DMTL39C Gastric adenocarcinoma 2B72 Phase 2 [2]
NUC-3373 DMQ0F5P Solid tumour/cancer 2A00-2F9Z Phase 1 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thymidylate synthase (TYMS) TT5FOMZ TYSY_HUMAN Modulator [1]

References

1 The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). Biochem Pharmacol. 1991 Oct 24;42(10):1885-95.
2 Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1112-8.
3 Clinical pipeline report, company report or official report of NuCana.