Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5FOMZ)

• DTT Name: Thymidylate synthase (TYMS)
• Synonyms: TSase; TS
• Gene Name: TYMS
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Methyltransferase
• UniProt ID: TYSY_HUMAN
• TTD ID: T98397
• EC Number: EC 2.1.1.45
• Sequence:
  MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
  MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
  LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
  AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
  TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
  YNPHPTIKMEMAV
• Function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
• KEGG Pathway:
  Pyrimidine metabolism (hsa00240)
  One carbon pool by folate (hsa00670)
  Metabolic pathways (hsa01100)
  Nucleotide metabolism (hsa01232)
  Antifolate resistance (hsa01523)
• Reactome Pathway:
  G1/S-Specific Transcription (R-HSA-69205)
  Interconversion of nucleotide di- and triphosphates (R-HSA-499943)
• BioCyc Pathway: MetaCyc:HS11096-MON

Molecular Interaction Atlas (MIA) of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Plevitrexed (R)-isomer	DMTL39C	Gastric adenocarcinoma	2B72	Phase 2	[2]
NUC-3373	DMQ0F5P	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ICI-198583	DMW4L3K	Discovery agent	N.A.	Investigative	[1]

References

• [1] The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). Biochem Pharmacol. 1991 Oct 24;42(10):1885-95.
• [2] Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1112-8.
• [3] Clinical pipeline report, company report or official report of NuCana.