General Information of Drug (ID: DMWA8B0)

Drug Name
JZL184 Drug Info
Synonyms JZL 184; JZL-184
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25021165
ChEBI ID
CHEBI:95015
CAS Number
CAS 1101854-58-3
TTD Drug ID
DMWA8B0

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Monoglyceride lipase (MAGL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABX-1431 DM9SYVJ Neuropathic pain 8E43.0 Phase 1 [3]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [4]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [4]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [4]
Pyrazole derivative 82 DMETCI3 N. A. N. A. Patented [4]
Pyrazole derivative 81 DMWT437 N. A. N. A. Patented [4]
PMID29053063-Compound-15 DM07U5R N. A. N. A. Patented [4]
Pyrazole derivative 80 DMQ3TGM N. A. N. A. Patented [4]
Carbamide derivative 24 DMD6Y73 N. A. N. A. Patented [4]
Piperazine carbamic compound 4 DMKZUO4 N. A. N. A. Patented [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoglyceride lipase (MAGL) TTZ963I MGLL_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5207).
2 Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.