Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWCJ1F)

Drug Name

OT-58 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Homocystinuria	5C50.B	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cystathionine beta-synthase (CBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Heme	DMGC287	Discovery agent	N.A.	Investigative	[3]
aminooxyacetic acid	DMHNDTW	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cystathionine beta-synthase (CBS)	TTVZJ7G	CBS_HUMAN	Replacement	[2]

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References

1	ClinicalTrials.gov (NCT03406611) OT-58 as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency. U.S. National Institutes of Health.
2	Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies. Biochimie. 2020 Jun;173:48-56.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1443).