Details of the Drug

General Information of Drug (ID: DMWCJ1F)

Drug Name

OT-58

Indication

Disease Entry	ICD 11	Status	REF
Homocystinuria	5C50.B	Phase 1/2	[1]
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Drug Type

Recombinant protein

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cystathionine beta-synthase (CBS)	TTVZJ7G	CBS_HUMAN	Replacement	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT03406611) OT-58 as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency. U.S. National Institutes of Health.
2	Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies. Biochimie. 2020 Jun;173:48-56.