Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWD1RC)

• Drug Name: PBI-1101 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Terminated	[1]

• Cross-matching ID: TTD Drug ID: DMWD1RC

Molecule-Related Drug Atlas

Drug(s) Targeting Pancreatic elastase 1 (CELA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[3]
Erdosteine	DM6QFSV	Bronchitis	CA20	Approved	[4]
Sivelestat	DM6BZCV	Crohn disease	DD70	Phase 3	[5]
Mdl 101,146	DMRSOBG	Inflammation	1A00-CA43.1	Terminated	[6]
WIN-63759	DMRV48P	Emphysema	CA21	Terminated	[7]
SSR-69071	DMWL4MI	Chronic obstructive pulmonary disease	CA22	Terminated	[8]
SYN-1134	DMG2SQM	Cystic fibrosis	CA25	Terminated	[9]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[6]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[10]
Dimethylformamide	DML6O4N	Discovery agent	N.A.	Investigative	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pancreatic elastase 1 (CELA1)	TT3NKIB	CELA1_HUMAN	Inhibitor	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018032)
• [2] CN patent application no. 1813706, Use of elastic protease inhibitor for preparing medicine for protecting cerebral hemorrhage.
• [3] Elastase inhibitors. J Soc Biol. 2001;195(2):143-50.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [5] Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome... Shock. 2010 Jan;33(1):14-8.
• [6] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [7] Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase. Drug Development Research Volume 34, Issue 3, pages 306-316, March 1995.
• [8] Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011 Aug 19;286(33):28889-901.
• [9] EP patent application no. 1292314, Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans.
• [10] Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
• [11] Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6.