Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWD42N)

Drug Name

4-fluorobenzoyl-Phe-Gly-Leu-Arg-Trp-NH2 Drug Info

Synonyms

CHEMBL388586; Peptide analogue, 1; SCHEMBL4132720; BDBM26338; FTM-080; N-[(4-fluorophenyl)carbonyl]-L-phenylalanylglycyl-L-leucyl-L-arginyl-L-tryptophanamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16735569
TTD Drug ID: DMWD42N

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting G-protein coupled receptor 54 (KISS1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TAK-683	DMRD8HK	Prostate cancer	2C82.0	Discontinued in Phase 1	[2]
kisspeptin-10	DMDL21W	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 54 (KISS1R)	TT3KBZY	KISSR_HUMAN	Inhibitor	[1]

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References

1	Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase. J Med Chem. 2008 Dec 11;51(23):7645-9.
2	Clinical pipeline report, company report or official report of Takeda (2009).
3	The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6.