Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWE1N8)

Drug Name

Cibacron blue Drug Info

Synonyms

Affi gel blue; Cibacron Blue F 3GA; Cibacron Blue 3G; Cibacronblau F3G-A; Procion Blue H-B; C.I. Reactive Blue 2; UNII-J0A052J6QF; Basilen Blue; CHEBI:34946; EINECS 235-465-0; NSC 328383; J0A052J6QF; C.I. 61211; 26763-68-8; 2-Anthracenesulfonic acid, 1-amino-4-((4-((4-chloro-6-((3(or 4)-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-; Affi-gel blue

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 172469
CAS Number: CAS 84166-13-2
TTD Drug ID: DMWE1N8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glutathione-dependent PGD synthase (HPGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Praziquantel	DMOU1PK	Flatworm infection	1F70-1F86	Approved	[3]
HF-0220	DMI4C90	Alzheimer disease	8A20	Phase 2	[4]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[5]
Protoporphyrin IX	DMWYE7A	Discovery agent	N.A.	Investigative	[6]
S-hexylglutathione	DMNWP02	Discovery agent	N.A.	Investigative	[7]
HQL-79	DMSHYQ3	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutathione-dependent PGD synthase (HPGDS)	TTCYE56	HPGDS_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1739).
2	A novel method for screening the glutathione transferase inhibitors. BMC Biochem. 2009 Mar 16;10:6.
3	X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):263-5.
4	US patent application no. 2009,0062,529, Multi-cyclic compounds.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic bene... Parasitol Res. 2008 Mar;102(4):805-7.
7	Purification and catalytic properties of glutathione transferase from the hepatopancreas of crayfish macrobrachium vollenhovenii (herklots). J Biochem Mol Toxicol. 2004;18(6):332-44.
8	Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86.