General Information of Drug (ID: DMWG98Z)

Drug Name
US9353089, 135 Drug Info
Synonyms CHEMBL2011974; SCHEMBL4232691; BDBM234502; BDBM50379890; US9353089, 135
Cross-matching ID
PubChem CID
11359820
TTD Drug ID
DMWG98Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9353089, 330 DMK02LS N. A. N. A. Patented [1]
US9353089, 327 DMB4MJ0 N. A. N. A. Patented [1]
Pepstatin DM9S1EA Malaria 1F40-1F45 Terminated [2]
Leupeptin DMU075F Malaria 1F40-1F45 Investigative [2]
E-64 DMMOPAK Discovery agent N.A. Investigative [3]
KNI-10006 DMMISH6 Discovery agent N.A. Investigative [4]
PS-777621 DM3F7SD Discovery agent N.A. Investigative [5]
PS-662477 DMT4YFR Discovery agent N.A. Investigative [6]
KNI-10740 DMPWY6H Discovery agent N.A. Investigative [4]
KNI-10265 DMQLB3T Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium Plasmepsin 2 (Malaria PLA2) TTXMNHO PLM2_PLAFA Inhibitor [1]

References

1 Compositions and methods for the treatment of malaria. US9353089.
2 Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
3 Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.
4 Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9.
5 High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.
6 Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20.
7 Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60.