Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWLIK1)

Drug Name
3-benzofuran-2-yl-2-benzothiazol-2-yl-3-oxo-propanenitrile Drug Info
Indication
Disease Entry ICD 11 Status REF
Glioma 2A00.0 Investigative [1]
Melanoma 2C30 Investigative [1]
Cross-matching ID
TTD Drug ID
DMWLIK1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting AP endonuclease 1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
APX3330 DMU6NBO Diabetic retinopathy 9B71.0 Phase 2 [2]
APX-3330 DMXIMQT Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
5-fluoro-1H-indole-2-carboxylic acid DM9U1HV Glioma 2A00.0 Investigative [1]
1,3-bis(1,3-benzothiazol-2-ylthio)acetone DMP86R3 Glioma 2A00.0 Investigative [1]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
AP endonuclease 1 (APEX1) TTHGL48 APEX1_HUMAN Inhibitor [1]

References

1 Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63.
2 Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. NPJ Precis Oncol. 2017;1:19.
3 Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Res. 2011 Jan;51(1):93-100.