Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWNKQ8)

• Drug Name: 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 1 Drug Info
• Synonyms: PMID27321640-Compound-[18F]-46
• Cross-matching ID: TTD Drug ID: DMWNKQ8

Molecule-Related Drug Atlas

Drug(s) Targeting Phosphodiesterase 2A (PDE2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofisopam	DMTGNWU	Hyperuricaemia	5C55.Y	Phase 2	[2]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[3]
ND7001	DMUBTC6	Mood disorder	6A60-6E23	Phase 1	[4]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMC8935	N. A.	N. A.	Patented	[1]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 2	DM4CSBD	N. A.	N. A.	Patented	[1]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 2	DMS3ROL	N. A.	N. A.	Patented	[1]
Triazolo-pyridine derivative 5	DM1R205	N. A.	N. A.	Patented	[1]
PMID27321640-Compound-58	DM0NYK3	N. A.	N. A.	Patented	[1]
Triazolo-pyridine derivative 4	DM5ZQKS	N. A.	N. A.	Patented	[1]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 3	DMZ61T8	N. A.	N. A.	Patented	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 2A (PDE2A)	TTJGW1Z	PDE2A_HUMAN	Inhibitor	[1]

References

• [1] Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46.
• [2] The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25.
• [3] Sulindac and its derivatives: a novel class of anticancer agents. Curr Opin Investig Drugs. 2001 May;2(5):677-83.
• [4] Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures. Neurosignals. 2013;21(3-4):197-212.