Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWOYCZ)

Drug Name

Ac-VEID-CHO Drug Info

Synonyms

Ac-VEID-CHO; CHEMBL478081; Ac-Val-Glu-Ile-Asp-CHO; acetyl-Val-Ile-Asp-aldehyde; GTPL8566; SCHEMBL20257260; acetyl-Val-Glu-Ile-Asp-aldehyde; N-acetyl-Val-Glu-Ile-Asp-aldehyde; ZINC14947179; BDBM50340548; 319494-39-8; N-Acetyl-Val-Glu-Ile-Asp-al, ~99% (HPLC), powder; (4S)-4-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-5-[[(2S,3S)-1-[[(2S)-1-carboxy-3-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15487887
TTD Drug ID: DMWOYCZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Caspase 6 messenger RNA (CASP6 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoquinoline-1,3,4(2H)-trione	DMT4RI2	Discovery agent	N.A.	Investigative	[3]
ISIS 134602	DMDS4BP	Discovery agent	N.A.	Investigative	[4]
ISIS 134583	DM0HWRN	Discovery agent	N.A.	Investigative	[4]
ISIS 134566	DMCM2S4	Discovery agent	N.A.	Investigative	[4]
ISIS 134524	DMFCOA5	Discovery agent	N.A.	Investigative	[4]
ISIS 134532	DMRFMVL	Discovery agent	N.A.	Investigative	[4]
ISIS 134609	DMYODMN	Discovery agent	N.A.	Investigative	[4]
ISIS 134608	DMVX9IT	Discovery agent	N.A.	Investigative	[4]
ISIS 134499	DM90TOR	Discovery agent	N.A.	Investigative	[4]
ISIS 134528	DMYZNIW	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caspase 6 messenger RNA (CASP6 mRNA)	TTKW4ML	CASP6_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8566).
2	Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91.
3	Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.
4	US patent application no. 6,566,135, Antisense modulation of caspase 6 expression.