General Information of Drug (ID: DMWXLK1)

Drug Name
Bis-aminopyrimidine derivative 5 Drug Info
Synonyms PMID27774824-Compound-Figure7ExampleI-13
Cross-matching ID
TTD Drug ID
DMWXLK1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Janus kinase 2 (JAK-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [2]
Baricitinib DM4ONW5 Rheumatoid arthritis FA20 Approved [3]
Ruxolitinib DM7Q98D Essential thrombocythemia 3B63.1Z Approved [4]
Pacritinib DM1T6ZN Myelofibrosis 2A20.2 Approved [5]
Fedratinib DM4ZBK6 Myelofibrosis 2A20.2 Approved [6]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [7]
XL019 DMJ6F5C Solid tumour/cancer 2A00-2F9Z Phase 3 [7]
Cerdulatinib DMSCR2H B-cell lymphoma 2A86 Phase 2 [8]
CTP-543 DM3SYOK Alopecia ED70 Phase 2 [9]
INCB039110 DMD9RV3 Malignant neoplasm 2A00-2F9Z Phase 2 [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting TYK2 tyrosine kinase (TYK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Deucravacitinib DMAR1YS Plaque psoriasis EA90.0 Approved [11]
PF-06700841 DMMGSFV Asthma CA23 Phase 2 [11]
PF-06826647 DM5H8V1 Plaque psoriasis EA90.0 Phase 2 [11]
PF-06826647 DM5H8V1 Plaque psoriasis EA90.0 Phase 2 [12]
NDI-034858 DM2FJE7 Psoriatic arthritis FA21 Phase 2 [13]
Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ N. A. N. A. Patented [1]
PMID27774824-Compound-Figure9Example2down DMXAV42 N. A. N. A. Patented [1]
Aminotriazolopyridine derivative 1 DMW2LZ0 N. A. N. A. Patented [1]
Imidazo[4,5-c]pyridine derivative 2 DMFDRJT N. A. N. A. Patented [1]
PMID27774824-Compound-Figure11Example1up DMH1W8F N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Inhibitor [1]
TYK2 tyrosine kinase (TYK2) TTBYWP2 TYK2_HUMAN Inhibitor [1]

References

1 Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143.
2 Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis.Leukemia.2015 Mar;29(3):741-4.
3 Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
4 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5 National Cancer Institute Drug Dictionary (drug id 609888).
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
7 Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
8 Company report (Portola Pharmaceuticals)
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048).
11 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
12 Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases. J Med Chem. 2020 Nov 25;63(22):13561-13577.
13 Clinical pipeline report, company report or official report of Nimbus Therapeutics