General Information of Drug (ID: DMWZLK6)

Drug Name
Indazoletriazolephenyl derivative 2 Drug Info
Synonyms PMID27310003-Compound-35
Cross-matching ID
TTD Drug ID
DMWZLK6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GS-5718 DMRKU0L Rheumatoid arthritis FA20 Phase 2 [2]
Zabedosertib DMEZGWP Atopic dermatitis EA80 Phase 2 [3]
CA-4948 DMWV8C6 Lymphoma 2A80-2A86 Phase 1 [4]
BAY1834845 DM8V62T Psoriasis vulgaris EA90 Phase 1 [5]
AZD6793 DM5GRZV Inflammation 1A00-CA43.1 Phase 1 [6]
SAR444656 DMIF2OL Atopic dermatitis EA80 Phase 1 [7]
Pyrazolopyrimidine and thienopyrimidine amide derivative 1 DM6TB4Z N. A. N. A. Patented [1]
Pyrazolopyrimidine and thienopyrimidine amide derivative 2 DMFUNH4 N. A. N. A. Patented [1]
Indazoletriazolephenyl derivative 1 DMHJDU6 N. A. N. A. Patented [1]
Indazole amide derivative 2 DMRPT5O N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrazolopyrimidine and thienopyrimidine amide derivative 1 DM6TB4Z N. A. N. A. Patented [1]
Pyrazolopyrimidine and thienopyrimidine amide derivative 2 DMFUNH4 N. A. N. A. Patented [1]
Indazoletriazolephenyl derivative 1 DMHJDU6 N. A. N. A. Patented [1]
WO2012007375C1 DMOZATX Discovery agent N.A. Investigative [8]
IRAK-1/4 inhibitor DMOQBGP Discovery agent N.A. Investigative [9]
WO2012007375C7 DMPI2MA Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
IL-1 receptor-associated kinase 1 (IRAK1) TTXAJWN IRAK1_HUMAN Inhibitor [1]
Renal carcinoma antigen NY-REN-64 (IRAK-4) TTKFVXR IRAK4_HUMAN Inhibitor [1]

References

1 Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32.
2 IRAK4 degrader to take on innate immunity. Nat Biotechnol. 2020 Nov;38(11):1221-1223.
3 Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomed Pharmacother. 2022 Sep;153:113459.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Clinical pipeline report, company report or official report of AstraZeneca
7 Clinical pipeline report, company report or official report of Sanofi
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2042).
9 Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.