Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX9ED1)

Drug Name

VU591 Drug Info

Synonyms

VU 591; VU-591

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Inward rectifier potassium channel Kir1.1 (KCNJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26004420-Compound-US20140309213B	DM0P4TA	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2013062900A	DM5N9M4	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2014099633D	DMJIZWR	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2013028474C	DMTCPNY	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2015017305F	DMLV6IY	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-U2014S0288042C	DM8RJTQ	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2013062900B	DMIM8UF	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2010129379A	DM37GMQ	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-US20140142115C	DMQ7Z5F	N. A.	N. A.	Patented	[3]
PMID26004420-Compound-WO2014015495A	DMRDUS9	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inward rectifier potassium channel Kir1.1 (KCNJ1)	TTJ13ST	KCNJ1_HUMAN	Blocker (channel blocker)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7696).
2	Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
3	Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51.