Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXAO4J)

Drug Name

SAR153191 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Ankylosing spondylitis	FA92.0	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Interleukin 6 receptor (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tocilizumab	DM7J6OR	Giant cell arteritis	4A44.2	Approved	[3]
Sarilumab	DMOGNXY	Rheumatoid arthritis	FA20	Approved	[4]
Sirukumab	DMK8AQP	Cutaneous lupus erythematosus	EB5Z	Phase 3	[5]
SA-237	DM7F2VG	Encephalopathy	8E47	Phase 3	[6]
Vobarilizumab	DM9KNJT	Rheumatoid arthritis	FA20	Phase 2	[7]
ALX-0061	DMO1VHC	Autoimmune diabetes	5A10	Phase 2	[8]
SBP-002	DM9F7R0	Melanoma	2C30	Terminated	[4]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[9]
FM-101	DMXK6EI	Multiple myeloma	2A83	Investigative	[5]
Sant7	DM9CV4P	Multiple myeloma	2A83	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7999).
2	Pharma & Vaccines. Product Development Pipeline. April 29 2009.
3	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2310).
6	IBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics International Conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA. MAbs. 2013 March 1; 5(2): 178-201.
7	Clinical pipeline report, company report or official report of Ablynx.
8	The preclinical pharmacology of the high affinity anti-IL-6R Nanobody ALX-0061 supports its clinical development in rheumatoid arthritis. Arthritis Res Ther. 2015 May 20;17:135.
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.